Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
نویسندگان
چکیده
منابع مشابه
Fat, Gluttony and Sloth: Obesity in Literature, Art and Medicine
The co-authors of this volume are David Haslam, the Chair and Clinical Director of the National Obesity Forum and Fiona Haslam, a former physician, art historian, and the author of a distinguished study of From Hogarth to Rowlandson: Medicine and Art in Eighteenth-Century Britain.(1) This summarizes both the strength and the weakness of this comprehensive study of the representation – and the r...
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Visceral fat obesity plays an essential role in the clustering of atherosclerotic multiple risk factors in the metabolic syndrome. However, the mechanism by which visceral fat obesity causes clustering of glucose intolerance, high blood pressure, and dyslipidemia remains unknown. We have proposed a “lipotoxicity theory” as the mechanism behind metabolic syndrome and its consequences: an excess ...
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E‐mail: [email protected] Whereas it is clear that obesity is a cardiovascular risk factor, the mechanisms linking expansion of the adipose tissue (AT) to these co-morbilities is uncertain. We think that inappropriate AT expandability and function is a key determinant of obesity-associated metabolic complications by initiating a lipotoxic proinflammatory cascade that affects essential metabolic o...
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The purpose of this study was to determine the role of lipotoxicity in vascular smooth muscle (VSM). C(1)-BODIPY 500/510 C(12) used to assess the ability of VSM A7r5 cells to transport long-chain fatty acids showed that lipid transport did not appear to limit metabolism. Thin layer chromatography revealed that storage of transported fatty acid occurred primarily as mono- and diglycerides and fa...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2010
ISSN: 1043-2760
DOI: 10.1016/j.tem.2010.01.009